Blockage of the Gut. Some people having promethazine/phenylephrine/codeine could produce severe constipation or possibly a blockage with the intestine (bowel obstruction).
There might be other Negative effects of promethazine/phenylephrine/codeine that are not shown in this article. Contact your Health care company if you're thinking that you will be aquiring a aspect outcome of the medicine.
Opvee® (nalmefene) is actually a nasal spray useful for the crisis procedure of a recognized or suspected opioid overdose in adults and kids ages twelve yrs and older. It's not a substitute for unexpected emergency clinical care.
Codeine is reported to show no evidence of carcinogenicity or mutagenicity in many different examination systems, such as the micronucleus and sperm abnormality assays and also the Salmonella assay. Promethazine was nonmutagenic in the Salmonella exam process of Ames.
Respiratory Despair in Young children The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers fewer than six decades of age.
オーストラリアとカナダでは、コデインは規制されているが、許可された薬剤師による最大15mg/錠での調合による入手が処方箋なしで可能である。
Get promethazine/phenylephrine/codeine particularly as prescribed. Convey to your healthcare service provider in the event you think that promethazine/phenylephrine/codeine is just not working. Phone your Health care provider at once or head to the nearest emergency place In case you have any of the subsequent really serious signs.
Epinephrine – As a result of potential for promethazine to reverse epinephrine’s vasopressor outcome, epinephrine should NOT be employed to take care of hypotension connected to promethazine click here overdose.
It is vital you eliminate undesirable opioid medicines safely and securely. Unused medicines is usually returned to any pharmacy. Really don't retain unused codeine 'just in the event'. This may lead to perilous or inappropriate use.
常見之不良反應有：瘙癢、噁心、嘔吐、昏睡、口乾、瞳孔縮小、姿態性低血壓（orthostatic hypotension）、小便不暢、便秘。
As an opioid, codeine might cause Bodily dependence and substance use dysfunction within just weeks of regular use.
When offered concomitantly with promethazine, the dose of barbiturates should be lowered by at the very least a single-50 percent, as well as dose of narcotics really should be lowered by 1-quarter to 1-50 %. Dosage need to be individualized. Excessive amounts of promethazine HCl relative to your narcotic may well bring about restlessness and motor hyperactivity in the client with discomfort; these symptoms usually disappear with adequate Charge of the agony.
The phosphate salt of codeine takes place as white, needle-shaped crystals or white crystalline powder. Codeine phosphate is freely soluble in water and a little soluble in Liquor.
Postmarketing circumstances of respiratory melancholy, such as fatalities, have already been described with usage of promethazine hydrochloride in pediatric patients fewer than 2 yrs of age. A variety of bodyweight-primarily based doses of promethazine hydrochloride have resulted in respiratory despair in these sufferers.