. Cytochrome P450 2D6 is the foremost enzyme accountable for the transformation of codeine to morphine and P450 3A4 is the main enzyme mediating the conversion of codeine to norcodeine
Breastfeeding. Tend not to just take promethazine/phenylephrine/codeine if you are breastfeeding. Promethazine/phenylephrine/codeine can move into breast milk. Inform your healthcare company Should you be breastfeeding or decide to breastfeed.
Acquire this medication by mouth as directed by your medical doctor. You could possibly consider this drug with or with no food. In case you have nausea, it may well support to just take this drug with foods.
投与方法は経口で、形状は錠、散、シロップがある。錠剤ではコデインはしばしばアセトアミノフェン、アスピリン、イブプロフェンと共に調合される。これらの組み合わせは、それぞれ単体での使用よりも良い疼痛コントロールが可能となる。
Inquire your medical professional or pharmacist if you need to have naloxone accessible to treat opioid overdose. Instruct Your loved ones or house members concerning the indications of an opioid overdose and how to deal with it.
オーストラリアとカナダでは、コデインは規制されているが、許可された薬剤師による最大15mg/錠での調合による入手が処方箋なしで可能である。
You may additionally experience lightheaded when getting up quickly from a lying or sitting position, so rise up little by little.
Opvee® must be administered right after initiation of CPR in a very lifetime-threatening unexpected emergency having a repeat dose as wanted. When compared with naloxone, Opvee® (nalmefene) has an extended duration of action and the next affinity for opioid receptors for that reason totally reversing opioid doses.
Bone-Marrow Despair – Promethazine need to be utilized with caution in people with bone-marrow despair. Leukopenia and agranulocytosis have already been noted, usually when promethazine HCl has become Utilized in association with other acknowledged marrow-harmful agents.
Promethazine: Promethazine can be a phenothiazine spinoff which differs structurally within the antipsychotic phenothiazines because of the presence of the branched side chain and no ring substitution. It is believed that this configuration is accountable for its relative deficiency (one/10 that of chlorpromazine) of dopamine antagonist Homes. Promethazine is undoubtedly an H 1 receptor blocking agent. In combination with its antihistaminic action, it provides clinically practical sedative and antiemetic consequences.
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This medicine may cause some individuals to be dizzy, drowsy, or a lot less notify than They can be Typically. Usually do not drive or do the rest that would be hazardous until you know how this medication affects you.
Promethazine is properly absorbed from your gastrointestinal tract. Scientific effects are apparent inside twenty minutes immediately after oral administration and usually previous four to 6 hrs, Despite the fact that they may persist as long as twelve several hours. Promethazine is metabolized because of the liver to various compounds; the sulfoxides of promethazine and N-demethylpromethazine would be the predominant metabolites showing in the urine.